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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
7 PT 1
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pubmed:dateCreated |
1976-9-1
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pubmed:abstractText |
A carcinoembryonic antigen (CEA-M) was purified from a hepatic metastasis obtained from a blood group O patient with cancer of the rectum. Using 125I-labeled carcinoembryonic antigen (CEA) and blood group antisera, H specificity has been found on the CEA-M. As the addition of anti-H to anti-CEA does not modify the extent of binding of labeled CEA-M to its antibodies (86%), the H and CEA determinants are carried by the same molecule. The affinity chromatography of CEA-M on an immunosorbent "anti-H-Sepharose" demonstrated that a proportion of CEA-M molecules might bear both H and CEA antigenic determinants. In addition, glycosyltransferases were used to modify the blood group H specificity into blood group A or B specificities.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
0008-5472
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
36
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
2124-9
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pubmed:dateRevised |
2004-11-17
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pubmed:meshHeading |
pubmed-meshheading:58713-ABO Blood-Group System,
pubmed-meshheading:58713-Antigens, Neoplasm,
pubmed-meshheading:58713-Binding Sites,
pubmed-meshheading:58713-Carcinoembryonic Antigen,
pubmed-meshheading:58713-Chromatography, Affinity,
pubmed-meshheading:58713-Epitopes,
pubmed-meshheading:58713-Galactose,
pubmed-meshheading:58713-Galactosyltransferases,
pubmed-meshheading:58713-Humans,
pubmed-meshheading:58713-Immune Sera,
pubmed-meshheading:58713-Uridine Diphosphate Galactose,
pubmed-meshheading:58713-Uridine Diphosphate N-Acetylgalactosamine
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pubmed:year |
1976
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pubmed:articleTitle |
Presence of blood group H antigen on a carcinoembryonic antigen, and its enzymatic modification into blood group A and B specificities.
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pubmed:publicationType |
Journal Article
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