Linked Life Data

582953

Source:http://linkedlifedata.com/resource/pubmed/id/582953

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
12
pubmed:dateCreated
1979-12-18
pubmed:abstractText
The penetration activity of cefamandole into different human tissues was studied under experimental conditions. The authors obtained samples of corticalis, spongiosa, cutis, subcutis, fascia and muscle during surgery in 42 cases. Cefamandole was given i.v. by means of: 1. single injections of 40 mg/kg body weight. 2. multiple injections with an initial dose of 40 mg/kg body weight and reinjections of 20 mg/kg body weight after reaching half-life, 3. permanent infusions of 50 mg/kg body weight per hour during 70 min. The investigation is based upon 482 serum level and 330 tissue level determinations. In case of tissue levels the extra- and intravascular concentrations had to be separated so that the contamination of the investigated samples by blood could be quantified. This was done first by the usual way of measuring the hemoglobin concentration, and additionally by the dextran method which was used for control of the hemoglobin method for the first time. The cefamandole conentrations following single and multiple injection did not show any differences in all tissues studied. Distinctly higher concentrations were found after permanent infusions, though with a considerably higher total dose.
pubmed:language
ger
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0004-4172
pubmed:author
pubmed:issnType
Print
pubmed:volume
28
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
2343-9
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1978
pubmed:articleTitle
[Studies on the diffusion rate of cefamandole in various human tissue (author's transl)].
pubmed:publicationType
Journal Article, English Abstract