5653211

pubmed:Citation

6

Studies were carried out to test the hypothesis that abnormal bile salt metabolism (interruption of the enterohepatic circulation) is responsible for steatorrhea in patients with ileal disease and (or) ileectomy.Duodenal bile salt concentration after a single, standard meal eaten at 8 a.m. was measured in 8 patients with ileectomy steatorrhea and compared with 11 normal control subjects and 7 hospitalized patients without gastrointestinal disease. Mean bile salt concentration was approximately half normal in the ileectomy group, but some of the patients fell well within the normal range, even on repeat studies. However, it was shown that the second and third meals eaten during a single day were associated with a marked depression of duodenal bile salt concentration in ileectomy patients, which suggested that the first meals in these patients flush out a large fraction of the bile salt pool. Simultaneously measured turnover studies with taurocholate-(14)C showed at t((1/2)) of 3.1 hr in these patients compared with 29.5 and 32 hr in two control subjects, proving that the enterohepatic circulation had indeed been interrupted by ileectomy. Hepatic synthesis can apparently partially reconstitute the bile salt pool during the overnight period. Additional studies were carried out to determine the relation between bile salt and micellar fat concentration in proximal small bowel contents after ingestion of the same standard meal. Below a bile salt concentration of 1.7 mg/ml, less than 0.8 mg/ml of lipid existed in the micellar phase of intestinal contents, whereas when bile salt concentration exceeded this level the amount of fat in the micellar phase rose progressively. Only 1 of 11 samples from three ileectomy patients had a micellar fat concentration > 0.8 mg/ml, whereas 33 of 42 samples from control subjects had micellar fat concentration > 0.8 mg/ml.Thus, abnormally low duodenal bile salt concentration during at least a portion of the day, with the associated depression of micellar fat, appears to be a major cause of decreased fat absorption in patients with ileectomy steatorrhea.

eng

AIM

MEDLINE

0021-9738

Print

NLM

1314-24

pubmed-meshheading:5653211-Adult, pubmed-meshheading:5653211-Bile Acids and Salts, pubmed-meshheading:5653211-Carbon Isotopes, pubmed-meshheading:5653211-Celiac Disease, pubmed-meshheading:5653211-Chromatography, Thin Layer, pubmed-meshheading:5653211-Duodenum, pubmed-meshheading:5653211-Fluorometry, pubmed-meshheading:5653211-Fluoroscopy, pubmed-meshheading:5653211-Humans, pubmed-meshheading:5653211-Ileum, pubmed-meshheading:5653211-Intestinal Absorption, pubmed-meshheading:5653211-Intubation, Gastrointestinal, pubmed-meshheading:5653211-Jejunum, pubmed-meshheading:5653211-Kidney, pubmed-meshheading:5653211-Lipid Metabolism, pubmed-meshheading:5653211-Spectrum Analysis, pubmed-meshheading:5653211-Vitamin B 12, pubmed-meshheading:5653211-Xylose

Bile salt and micellar fat concentration in proximal small bowel contents of ileectomy patients.