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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
6
|
pubmed:dateCreated |
1977-7-18
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pubmed:abstractText |
Myasthenia gravis developed in two children at 2 and 3 years of age respectively. Minimal improvement followed chronic oral administration of cholinesterase inhibitors. Patient 1 had ptosis and ophthalmoplegia but no clinical or electromyographic involvement of muscles of the extremities, although a quadriceps muscle biopsy revealed lymphorrhages. Patient 2 had progressive generalized myasthenia for 3 1/2 years. Both children were given a 3-month course of prednisone followed by thymectomy. They both are in remission, 12 and 8 months after thymectomy, with only minimal residual ocular weakness, but this weakness is much more responsive to anticholinesterase drugs than before thymectomy. Long-term administration of steroids, with the attendant complication of growth retardation, is avoided.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
0028-3878
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
27
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
550-3
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pubmed:dateRevised |
2004-11-17
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pubmed:meshHeading |
pubmed-meshheading:559263-Age Factors,
pubmed-meshheading:559263-Child, Preschool,
pubmed-meshheading:559263-Female,
pubmed-meshheading:559263-Humans,
pubmed-meshheading:559263-Male,
pubmed-meshheading:559263-Myasthenia Gravis,
pubmed-meshheading:559263-Prednisone,
pubmed-meshheading:559263-Thymectomy
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pubmed:year |
1977
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pubmed:articleTitle |
Effective treatment of infantile myasthenia gravis by combined prednisone and thymectomy.
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pubmed:publicationType |
Journal Article,
Case Reports
|