|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
7944
|
|
pubmed:dateCreated |
1976-2-9
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|
pubmed:abstractText |
The effects of two dose regimens of cimetidine on 24 h intragastric acidity were investigated in six patients with duodenal ulcer. They received placebo capsules on the first day and cimetidine on the second day. Cimetidine 0-8 g/day decreased 24 h mean H+ activity by 55% but 1-6 g/day decreased it by 67%, the difference being due to a greater nocturnal decrease in the high-dose group. Intragastric pH remained below 2-0 for much of the treatment day but similar values were found in four post-vagotomy patients. Cimetidine 0-8-1-6 g/day results in a decrease of intragastric acidity that is compatible with successful medical treatment of duodenal ulceration.
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pubmed:language |
eng
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|
pubmed:journal |
|
|
pubmed:citationSubset |
AIM
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|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Nov
|
|
pubmed:issn |
0140-6736
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
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pubmed:day |
29
|
|
pubmed:volume |
2
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
1069-72
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|
pubmed:dateRevised |
2004-11-17
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pubmed:meshHeading |
pubmed-meshheading:53554-Circadian Rhythm,
pubmed-meshheading:53554-Duodenal Ulcer,
pubmed-meshheading:53554-Fasting,
pubmed-meshheading:53554-Gastric Acidity Determination,
pubmed-meshheading:53554-Gastric Juice,
pubmed-meshheading:53554-Gastrins,
pubmed-meshheading:53554-Guanidines,
pubmed-meshheading:53554-Histamine H1 Antagonists,
pubmed-meshheading:53554-Humans,
pubmed-meshheading:53554-Hydrogen-Ion Concentration,
pubmed-meshheading:53554-Imidazoles,
pubmed-meshheading:53554-Male,
pubmed-meshheading:53554-Placebos,
pubmed-meshheading:53554-Vagotomy
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|
pubmed:year |
1975
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|
pubmed:articleTitle |
24-hour control of intragastric acidity by cimetidine in duodenal-ulcer patients.
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|
pubmed:publicationType |
Journal Article,
Clinical Trial,
Controlled Clinical Trial
|
