rdf:type |
|
lifeskim:mentions |
umls-concept:C0008359,
umls-concept:C0008976,
umls-concept:C0030211,
umls-concept:C0035171,
umls-concept:C0240919,
umls-concept:C0302523,
umls-concept:C0439234,
umls-concept:C0684224,
umls-concept:C0700325,
umls-concept:C1274040,
umls-concept:C1521738,
umls-concept:C1707877
|
pubmed:issue |
2
|
pubmed:dateCreated |
1969-9-30
|
pubmed:abstractText |
A controlled cholera vaccine field trial was carried out in rural East Pakistan during the 1966-67 cholera season. A commercial cholera vaccine of average potency was tested in 40 000 children aged 3 months to 14 years in 1- and 2-dose schedules. In the cholera season extending for 8 months following immunization, a single dose produced an over-all protection of 46%; 2 doses at an interval of 1 month provided 64% protection. The single dose was virtually ineffective in children under 5 years, but provided significant protection in older children. The enhanced effect of the 2-dose schedule was primarily due to the boosting of protection in children under the age of 5 years. The duration of significant protection, even with the 2-dose schedule, did not appear to extend beyond the first 3 months of the 8-month cholera season.
|
pubmed:commentsCorrections |
|
pubmed:language |
eng
|
pubmed:journal |
|
pubmed:citationSubset |
IM
|
pubmed:chemical |
|
pubmed:status |
MEDLINE
|
pubmed:issn |
0042-9686
|
pubmed:author |
|
pubmed:issnType |
Print
|
pubmed:volume |
40
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
177-85
|
pubmed:dateRevised |
2010-10-26
|
pubmed:meshHeading |
pubmed-meshheading:5306538-Adolescent,
pubmed-meshheading:5306538-Adult,
pubmed-meshheading:5306538-Age Factors,
pubmed-meshheading:5306538-Child,
pubmed-meshheading:5306538-Child, Preschool,
pubmed-meshheading:5306538-Cholera,
pubmed-meshheading:5306538-Cholera Vaccines,
pubmed-meshheading:5306538-Female,
pubmed-meshheading:5306538-Humans,
pubmed-meshheading:5306538-Immunization Schedule,
pubmed-meshheading:5306538-Infant,
pubmed-meshheading:5306538-Infant, Newborn,
pubmed-meshheading:5306538-Male,
pubmed-meshheading:5306538-Pakistan,
pubmed-meshheading:5306538-Population Surveillance,
pubmed-meshheading:5306538-Rural Population
|
pubmed:year |
1969
|
pubmed:articleTitle |
Report of the 1966-67 cholera vaccine field trial in rural East Pakistan. I. Study design and results of the first year of observation.
|
pubmed:publicationType |
Journal Article,
Clinical Trial,
Controlled Clinical Trial
|