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rdf:type |
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lifeskim:mentions |
umls-concept:C0003241,
umls-concept:C0007634,
umls-concept:C0020971,
umls-concept:C0025914,
umls-concept:C0026809,
umls-concept:C0205087,
umls-concept:C0220781,
umls-concept:C0332311,
umls-concept:C0332461,
umls-concept:C0392747,
umls-concept:C0439851,
umls-concept:C0439852,
umls-concept:C0443172,
umls-concept:C1510827,
umls-concept:C1517945,
umls-concept:C1552596,
umls-concept:C1883254,
umls-concept:C1947931,
umls-concept:C2587213,
umls-concept:C2603343
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pubmed:issue |
4
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pubmed:dateCreated |
1976-2-2
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pubmed:abstractText |
The change in avidity of anti-hapten antibody with time after immunization was studied in mice at the level of the antibody-forming cell. A progressive increase in avidity was seen in both direct and indirect plaque-forming cells. Late (38 days) after immunization with a large dose of antigen there was a preferential loss of high avidity plaque-forming cells and the average avidity decreased. High avidity memory cells were still present since boosting resulted in the prompt appearance of very high avidity plaque-forming cells. There was a strong positive correlation between the avidity of the direct and the indirect plaque-forming cells present in the same spleen. A pattern of change in avidity and heterogeneity of avidity similar to that observed with intact animals was seen in lethally irradiated mice reconstituted with normal spleen and thymus cells.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/52616-13413090,
http://linkedlifedata.com/resource/pubmed/commentcorrection/52616-14214095,
http://linkedlifedata.com/resource/pubmed/commentcorrection/52616-4100636,
http://linkedlifedata.com/resource/pubmed/commentcorrection/52616-4115687,
http://linkedlifedata.com/resource/pubmed/commentcorrection/52616-4117562,
http://linkedlifedata.com/resource/pubmed/commentcorrection/52616-4123958,
http://linkedlifedata.com/resource/pubmed/commentcorrection/52616-4142444,
http://linkedlifedata.com/resource/pubmed/commentcorrection/52616-4169440,
http://linkedlifedata.com/resource/pubmed/commentcorrection/52616-4194305,
http://linkedlifedata.com/resource/pubmed/commentcorrection/52616-4469223,
http://linkedlifedata.com/resource/pubmed/commentcorrection/52616-4563878,
http://linkedlifedata.com/resource/pubmed/commentcorrection/52616-4568183,
http://linkedlifedata.com/resource/pubmed/commentcorrection/52616-4574576,
http://linkedlifedata.com/resource/pubmed/commentcorrection/52616-4579961,
http://linkedlifedata.com/resource/pubmed/commentcorrection/52616-4616762,
http://linkedlifedata.com/resource/pubmed/commentcorrection/52616-4624679,
http://linkedlifedata.com/resource/pubmed/commentcorrection/52616-4628493,
http://linkedlifedata.com/resource/pubmed/commentcorrection/52616-4867490,
http://linkedlifedata.com/resource/pubmed/commentcorrection/52616-4900673,
http://linkedlifedata.com/resource/pubmed/commentcorrection/52616-4904002,
http://linkedlifedata.com/resource/pubmed/commentcorrection/52616-4927596,
http://linkedlifedata.com/resource/pubmed/commentcorrection/52616-5060293,
http://linkedlifedata.com/resource/pubmed/commentcorrection/52616-5061979
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
0019-2805
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
29
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
629-41
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pubmed:dateRevised |
2011-11-17
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pubmed:meshHeading |
pubmed-meshheading:52616-Animals,
pubmed-meshheading:52616-Antibody Formation,
pubmed-meshheading:52616-Antibody Specificity,
pubmed-meshheading:52616-Antibody-Producing Cells,
pubmed-meshheading:52616-Antigen-Antibody Reactions,
pubmed-meshheading:52616-Binding Sites, Antibody,
pubmed-meshheading:52616-Haptens,
pubmed-meshheading:52616-Hemolytic Plaque Technique,
pubmed-meshheading:52616-Immunization,
pubmed-meshheading:52616-Immunologic Memory,
pubmed-meshheading:52616-Male,
pubmed-meshheading:52616-Mice,
pubmed-meshheading:52616-Spleen,
pubmed-meshheading:52616-Thymus Gland,
pubmed-meshheading:52616-Time Factors,
pubmed-meshheading:52616-gamma-Globulins
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pubmed:year |
1975
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pubmed:articleTitle |
Studies on the control of antibody synthesis. VII. Change in affinity of direct and indirect plaque-forming cells with time after immunization in the mouse: loss of high affinity plaques late after immunization.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
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