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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
4
|
pubmed:dateCreated |
1980-3-17
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pubmed:abstractText |
The authors investigated the pharmacokinetics of the pressor substance 5,8-dimetoxy-trans-2-/2-hydroxyethyl/-amino-3-hydroxy-1,2,3,4-tetrahydronaphthaline hydrochloride (1b), which possessed strong pressor action. Blood concentrations after venous administration in a dose of 1 mg/kg of body weight were determined by means of exctration spectrofluorometric method. The data complied with the biexponential equation, meeting the requirements of an open two-compartment model. There was a quick elimination of the substance from the central compartment, which correlated also with the data for quick disappearances of the effect on the arterial pressure.
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pubmed:language |
bul
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pubmed:journal | |
pubmed:citationSubset |
IM
|
pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:issn |
0367-0643
|
pubmed:author | |
pubmed:issnType |
Print
|
pubmed:volume |
18
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
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pubmed:pagination |
229-34
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pubmed:dateRevised |
2009-11-11
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pubmed:meshHeading |
pubmed-meshheading:520273-Animals,
pubmed-meshheading:520273-Blood Pressure,
pubmed-meshheading:520273-Drug Evaluation, Preclinical,
pubmed-meshheading:520273-Injections, Intravenous,
pubmed-meshheading:520273-Kinetics,
pubmed-meshheading:520273-Male,
pubmed-meshheading:520273-Naphthalenes,
pubmed-meshheading:520273-Rabbits,
pubmed-meshheading:520273-Tetrahydronaphthalenes,
pubmed-meshheading:520273-Time Factors,
pubmed-meshheading:520273-Vasoconstrictor Agents
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pubmed:year |
1979
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pubmed:articleTitle |
[Pharmacokinetics of the pressor substance, 5,8-dimethoxy-trans-2-(2-hydroxyethyl)-amino-3-hydroxy-1,2,3,4-tetrahydronaphthalene hydrochloride (1b), after intravenous use].
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pubmed:publicationType |
Journal Article,
English Abstract
|