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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
1
|
| pubmed:dateCreated |
1975-11-8
|
| pubmed:abstractText |
Silybine is the main active substance of the polyhydroxyphenylchromanone derivatives extracted from the seeds of Silybum Marianum. In the normal albinos rat, this pure compound (from 2 mg/100 g) lowers directly the systemic blood pressure. It does not increase vascular permeability. It potentiates post-serotonine hypertension. Silybine antagonizes cutaneous oedemas and suppresses the fall of blood pressure induced by dextran polymers. It inhibits anaphylactic shock in rats sensitized by ovalbumine. Silybine seems to be a stabilizer of mastcells membranes, thus preventing histamine release.
|
| pubmed:language |
fre
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Mar
|
| pubmed:issn |
0301-4533
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
214
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
165-76
|
| pubmed:dateRevised |
2006-11-15
|
| pubmed:meshHeading |
pubmed-meshheading:50765-Anaphylaxis,
pubmed-meshheading:50765-Animals,
pubmed-meshheading:50765-Blood Pressure,
pubmed-meshheading:50765-Capillary Permeability,
pubmed-meshheading:50765-Dextrans,
pubmed-meshheading:50765-Flavonoids,
pubmed-meshheading:50765-Histamine H1 Antagonists,
pubmed-meshheading:50765-Histamine Release,
pubmed-meshheading:50765-Rats,
pubmed-meshheading:50765-Silymarin
|
| pubmed:year |
1975
|
| pubmed:articleTitle |
[General pharmacologic properties of silybine and silymarine in the rat].
|
| pubmed:publicationType |
Journal Article,
In Vitro,
English Abstract
|