Linked Life Data

504332

Source:http://linkedlifedata.com/resource/pubmed/id/504332

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
7
pubmed:dateCreated
1980-1-28
pubmed:abstractText
The actions of both Substance P, a potential neurotransmitter or modulator and of a shortened analogue on learning and memorizing processes are reported in this paper. Sixty male rats, aged 22, 14, and 10 weeks, were exposed to Substance P (Arg-Pro-Gln-Gln-Phe-Gly-Leu-MetNH2) and to a shortened hexapeptide analogue (Lys-Phe-Ile-Gly-Leu-MetNH2), doses being 250 microgram/kg and 500 microgram/kg, to test their action upon learning and memorizing processes, such as acquisition, retention, and ecphoration, by means of a conditioned-reflex locomotor defense method. Response time of all three age groups as well their retention and ecphoration were normal under the impact of hexapeptide. The effects of Substance P were decline of retention in juvenile animals (10 weeks of age) and coupling between the processes of central-nervous afference synthesis, on the one hand, and the efference integral related to motoricity, on the other, in both juvenile and adult animals. A retention test was conducted and showed that discontinuation of application of either peptide over 4 d was followed by complete inhibition of ecphoration. Learning and memorising processes were restorable by reapplication of the peptides. These findings were defined as "state-dependent learning". Only slight variation under the impact of both Substance P and the analogue was recordable by non-invasive measurement of systolic blood pressure.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jul
pubmed:issn
0031-7144
pubmed:author
pubmed:issnType
Print
pubmed:volume
34
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
419-23
pubmed:dateRevised
2007-1-29
pubmed:meshHeading
pubmed:year
1979
pubmed:articleTitle
Conditioned-reflex learning of normal juvenile and adult rats exposed to action of substance P and of an SP analogue.
pubmed:publicationType
Journal Article