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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
6
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pubmed:dateCreated |
1975-9-9
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pubmed:abstractText |
The ability of thymus-derived lymphocytes (T cells) from BALB/c mice to recognize the individually specific antigenic determinants (idiotypes) of BALB/c myeloma proteins was tested. Spleen cells from donor mice immunized with a given myeloma protein greatly augmented the response of hapten-specific bone marrow-derived, thymus-independent lymphocytes (cells) to a hapten conjugate of the immunizing myeloma protein. This helper effect was specific for the myeloma protein idiotype; responses to hapten conjugates of similar myeloma proteins, bearing different idiotypic determinants, were not augmented by these spleen cells. That the helper cell is a T cell was shown by its marked sensitivity to cytolysis with an isoantiserum specific for T cells (anti-Thy-1-2) and complement. The discrimination between idiotypes by such T cells is roughly comparable to that of the antibody produced by the donors of the helper cells.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/49059-1086213,
http://linkedlifedata.com/resource/pubmed/commentcorrection/49059-4103271,
http://linkedlifedata.com/resource/pubmed/commentcorrection/49059-4108872,
http://linkedlifedata.com/resource/pubmed/commentcorrection/49059-4109878,
http://linkedlifedata.com/resource/pubmed/commentcorrection/49059-4125439,
http://linkedlifedata.com/resource/pubmed/commentcorrection/49059-4129807,
http://linkedlifedata.com/resource/pubmed/commentcorrection/49059-4130243,
http://linkedlifedata.com/resource/pubmed/commentcorrection/49059-4131516,
http://linkedlifedata.com/resource/pubmed/commentcorrection/49059-4133999,
http://linkedlifedata.com/resource/pubmed/commentcorrection/49059-4140517,
http://linkedlifedata.com/resource/pubmed/commentcorrection/49059-4193611,
http://linkedlifedata.com/resource/pubmed/commentcorrection/49059-4214865,
http://linkedlifedata.com/resource/pubmed/commentcorrection/49059-4598645,
http://linkedlifedata.com/resource/pubmed/commentcorrection/49059-46185,
http://linkedlifedata.com/resource/pubmed/commentcorrection/49059-47219,
http://linkedlifedata.com/resource/pubmed/commentcorrection/49059-4728684,
http://linkedlifedata.com/resource/pubmed/commentcorrection/49059-4758898,
http://linkedlifedata.com/resource/pubmed/commentcorrection/49059-5059886,
http://linkedlifedata.com/resource/pubmed/commentcorrection/49059-5083512,
http://linkedlifedata.com/resource/pubmed/commentcorrection/49059-5817170,
http://linkedlifedata.com/resource/pubmed/commentcorrection/49059-5919593
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
0027-8424
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
72
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
2357-60
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:49059-Animals,
pubmed-meshheading:49059-B-Lymphocytes,
pubmed-meshheading:49059-Complement System Proteins,
pubmed-meshheading:49059-Cytotoxicity Tests, Immunologic,
pubmed-meshheading:49059-Epitopes,
pubmed-meshheading:49059-Haptens,
pubmed-meshheading:49059-Hemocyanin,
pubmed-meshheading:49059-Immunization,
pubmed-meshheading:49059-Mice,
pubmed-meshheading:49059-Mice, Inbred BALB C,
pubmed-meshheading:49059-Myeloma Proteins,
pubmed-meshheading:49059-Nitrobenzenes,
pubmed-meshheading:49059-Ovalbumin,
pubmed-meshheading:49059-Rabbits,
pubmed-meshheading:49059-Spleen,
pubmed-meshheading:49059-T-Lymphocytes
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pubmed:year |
1975
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pubmed:articleTitle |
Recognition of immunoglobulin idiotypes by thymus-derived lymphocytes.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
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