Linked Life Data

4899873

Source:http://linkedlifedata.com/resource/pubmed/id/4899873

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
1969-12-16
pubmed:abstractText
The experiments presented in this paper demonstrate that glucose transport via the phosphoenolpyruvate-phosphotransferase system as studied in isolated E. coli membrane preparations is subject to regulation by sugar-P's. Glucose transport in these preparations is inhibited by glucose-6-P, glucose-1-P, and, to a lesser extent, by other P-esters. There appear to be two inhibitory sites, one specific for glucose-1-P and related sugar-1-P's and the other specific for glucose-6-P and related sugar-6-P's. The inhibition by these sugar-P's is noncompetitive, and the inhibitory sites are separate, subject to independent control, and apparently are accessible from outside the membrane. Furthermore, glucose-6-P is able to reverse partially inhibition of glucose transport by glucose-1-P and vice versa. Preliminary evidence is presented indicating that glucose-1-P may play a central role in the regulation of sugar transport in general, by virtue of its ability to inhibit selectively the transport of sugars other than glucose.
pubmed:commentsCorrections
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jul
pubmed:issn
0027-8424
pubmed:author
pubmed:issnType
Print
pubmed:volume
63
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
724-31
pubmed:dateRevised
2009-11-18
pubmed:meshHeading
pubmed:year
1969
pubmed:articleTitle
Regulation of sugar transport in isolated bacterial membrane preparations from Escherichia coli.
pubmed:publicationType
Journal Article