Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1979-12-27
pubmed:abstractText
1 Measurements of the binding of 12-alpha-[3H]-digoxin to the membranes of intact erythrocytes, erythrocyte 86rubidium uptake and intraerythrocytic sodium concentrations have been made in the red cells of various groups of patients--those who have not received digoxin, those during the early phases of treatment, those during chronic (greater than 2 months) treatment, and those toxic. 2 The values of those measurements in the patients in the early phases of therapy and in the toxic patients differed significantly from those of the untreated patients. 3 However, the values in the chronically treated patients were not different from those of the untreated patients. 4 The results suggest that the biochemical pharmacological effects of digoxin which occur during the early phases of therapy do not persist in the long-term. 5 The possible clinical significance of these observations is discussed.
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/486290-1175256, http://linkedlifedata.com/resource/pubmed/commentcorrection/486290-13142506, http://linkedlifedata.com/resource/pubmed/commentcorrection/486290-132355, http://linkedlifedata.com/resource/pubmed/commentcorrection/486290-322793, http://linkedlifedata.com/resource/pubmed/commentcorrection/486290-4262774, http://linkedlifedata.com/resource/pubmed/commentcorrection/486290-4506784, http://linkedlifedata.com/resource/pubmed/commentcorrection/486290-4741924, http://linkedlifedata.com/resource/pubmed/commentcorrection/486290-4819523, http://linkedlifedata.com/resource/pubmed/commentcorrection/486290-486288, http://linkedlifedata.com/resource/pubmed/commentcorrection/486290-486289, http://linkedlifedata.com/resource/pubmed/commentcorrection/486290-5076391, http://linkedlifedata.com/resource/pubmed/commentcorrection/486290-5352988, http://linkedlifedata.com/resource/pubmed/commentcorrection/486290-5388455, http://linkedlifedata.com/resource/pubmed/commentcorrection/486290-5416783, http://linkedlifedata.com/resource/pubmed/commentcorrection/486290-5429654, http://linkedlifedata.com/resource/pubmed/commentcorrection/486290-602591, http://linkedlifedata.com/resource/pubmed/commentcorrection/486290-684152, http://linkedlifedata.com/resource/pubmed/commentcorrection/486290-72958, http://linkedlifedata.com/resource/pubmed/commentcorrection/486290-861136, http://linkedlifedata.com/resource/pubmed/commentcorrection/486290-861137
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Aug
pubmed:issn
0306-5251
pubmed:author
pubmed:issnType
Print
pubmed:volume
8
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
135-42
pubmed:dateRevised
2009-11-18
pubmed:meshHeading
pubmed:year
1979
pubmed:articleTitle
The acute changes seen in cardiac glycoside receptor sites, 86rubidium uptake and intracellular sodium concentrations in the erythrocytes of patients during the early phases of digoxin therapy are not found during chronic therapy: pharmacological and therapeutic implications for chronic digoxin therapy.
pubmed:publicationType
Journal Article