rdf:type |
|
lifeskim:mentions |
|
pubmed:issue |
3
|
pubmed:dateCreated |
1979-11-21
|
pubmed:abstractText |
Ability of the beta-subunit of human chorionic gonadotropin to inhibit the response to lutropin (luteinizing hormone, LH) was tested in the immature rat ovarian system and pregnant-mare-serum-gonadotropin-primed rat ovarian system with progesterone production being used as the response. Human chorionic gonadotropin beta-subunit was found to inhibit human and ovine lutropin-stimulated progesterone production. At a constant dose of lutropin, inhibition was dependent on the concentration of beta-subunit. When concentration of the beta-subunit was kept constant at 5.0 microgram/ml and the concentration of lutropin was varied, the inhibition was maximum at the saturating concentration of the native hormone. The alpha-subunit of the human chorionic gonadotropin did not inhibit the response to lutropin. The lutropin/beta-subunit ratio required to produce an inhibition of response was much lower than that required to bring about an observable inhibition of binding.
|
pubmed:commentsCorrections |
|
pubmed:language |
eng
|
pubmed:journal |
|
pubmed:citationSubset |
IM
|
pubmed:chemical |
|
pubmed:status |
MEDLINE
|
pubmed:month |
Jun
|
pubmed:issn |
0264-6021
|
pubmed:author |
|
pubmed:issnType |
Print
|
pubmed:day |
15
|
pubmed:volume |
180
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
573-8
|
pubmed:dateRevised |
2009-11-18
|
pubmed:meshHeading |
pubmed-meshheading:486134-Animals,
pubmed-meshheading:486134-Chorionic Gonadotropin,
pubmed-meshheading:486134-Depression, Chemical,
pubmed-meshheading:486134-Dose-Response Relationship, Drug,
pubmed-meshheading:486134-Female,
pubmed-meshheading:486134-Luteinizing Hormone,
pubmed-meshheading:486134-Ovary,
pubmed-meshheading:486134-Progesterone,
pubmed-meshheading:486134-Rats
|
pubmed:year |
1979
|
pubmed:articleTitle |
Ability of human chorionic gonadotropin beta-subunit to inhibit the steroidogenic response to lutropin.
|
pubmed:publicationType |
Journal Article
|