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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
1974-11-8
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pubmed:abstractText |
Plasma luteinizing hormone (LH) and testosterone (T) were measured by radioimmunoassay in nine pubertal boys and three sexually mature young men at 20-min intervals for 24 h. Plasma LH and T were also measured in one boy during a delayed sleep onset study. Polygraphic monitoring was carried out to identify precisely sleep onset. Wakefulness, and specific sleep stages. In all nine pubertal boys the plasma T concentration fluctuated and was significantly higher during normal nocturnal sleep as compared to daytime waking. This increased T secretion during sleep was temporally linked to the characteristic pubertal sleep augmentation of LH secretion. To define further the relationship of this increased T secretion to sleep, plasma LH and T were also measured in three of the pubertal boys after acute (1-day) reversal of the sleep-wake cycle. One of these boys was also studied after 3 days of sleep-wake cycle reversal. The results of these studies showed that plasma T was now augmented during the reversed daytime sleep period; the mean T concentrations during this period were significantly higher (P < 0.001) than during nocturnal waking in all four studies. Measurement of plasma LH and T in the three sexually mature young men showed episodic secretion of LH and T during both waking and sleep periods; there was no consistent significant augmentation of LH or T secretion during sleep. This study demonstrates that (a) in normal pubertal boys and sexually mature young men plasma T fluctuates episodically; (b) there is marked augmentation of T secretion during sleep in pubertal boys, which is dependent on increased LH secretion; (c) this pubertal LH-T secretory "program" is dependent on sleep, since it shifts with delayed sleep onset and reversal of the sleep-wake cycle; and (d) this demonstrable tropic effect of LH on T is evident only during puberty, since sexually mature young men fail to show any consistent relationship between LH and T secretion either awake or asleep.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/4852310-14450081,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4852310-4272160,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4852310-4302180,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4852310-4302913,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4852310-4306481,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4852310-4307378,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4852310-4314077,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4852310-4326799,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4852310-4332761,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4852310-4341276,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4852310-4350348,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4852310-4352270,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4852310-4361974,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4852310-4681772,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4852310-4683184,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4852310-4683409,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4852310-4686377,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4852310-4706201,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4852310-4742536,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4852310-5012772,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4852310-5032517,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4852310-5057627,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4852310-5066114,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4852310-5135635,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4852310-5379879,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4852310-5450378,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4852310-5470210,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4852310-5571101,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4852310-5675428,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4852310-5904534,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4852310-5950482,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4852310-6018579,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4852310-6073997
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
0021-9738
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
54
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
609-18
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:4852310-Adolescent,
pubmed-meshheading:4852310-Adult,
pubmed-meshheading:4852310-Central Nervous System,
pubmed-meshheading:4852310-Child,
pubmed-meshheading:4852310-Electroencephalography,
pubmed-meshheading:4852310-Humans,
pubmed-meshheading:4852310-Luteinizing Hormone,
pubmed-meshheading:4852310-Male,
pubmed-meshheading:4852310-Periodicity,
pubmed-meshheading:4852310-Puberty,
pubmed-meshheading:4852310-Radioimmunoassay,
pubmed-meshheading:4852310-Secretory Rate,
pubmed-meshheading:4852310-Sleep,
pubmed-meshheading:4852310-Sleep Deprivation,
pubmed-meshheading:4852310-Testosterone,
pubmed-meshheading:4852310-Time Factors
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pubmed:year |
1974
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pubmed:articleTitle |
Human puberty. Simultaneous augmented secretion of luteinizing hormone and testosterone during sleep.
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pubmed:publicationType |
Journal Article
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