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pubmed-article:46833pubmed:abstractTextNeonatal liver or adult spleen was used as a source of B-lymphocytes in reconstituting lethally irradiated, syngeneic mice. Recipients were all given excess adult, syngeneic thymus cells and were immunized with dinitrophenylated bovine gamma globulin. The distribution of avidities of plaque-forming cells produced by immunized recipients of neonatal liver was highly restricted in comparison with animals reconstituted with adult spleen indicating a restriction of B-lymphocyte heterogeneity in the neonatal mouse.lld:pubmed
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pubmed-article:46833pubmed:articleTitleOntogeny of B-lymphocyte function with respect to the heterogeneity of antibody affinity-1,2.lld:pubmed
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