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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
4
|
pubmed:dateCreated |
1975-6-7
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pubmed:abstractText |
Serum alpha-fetoprotein levels were measured by a sensitive double-antibody radioimmunoassay in 580 patients with a variety of malignant and nonmalignant gastrointestinal diseases to determine the incidence of levels elevated above 40 ng/ml. Over 200 normal control subjects have all had levels below 40 ng/ml. Fifteen % of 95 patients with gastric carcinoma, 3 percent of 191 patients with colorectal carcinoma, 24 percent of 45 patients with pancreatic carcinoma, 25 percent of 8 patients with biliary tract carcinoma, and 70 percent of 73 patients with hepatocellular carcinoma had elevated serum alpha-fetoprotein. None of 14 patients with esophageal or small bowel carcinoma had elevated levels. In contrast, 1 percent of 154 patients with nonmalignant, nonhepatic gastrointestinal disease had elevations of serum alpha-fetoprotein. Alpha-Fetoprotein appears to be a potential marker for tumor activity in some patients with certain gastrointestinal cancers.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
0008-5472
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
35
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
991-6
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:46783-Adult,
pubmed-meshheading:46783-Aged,
pubmed-meshheading:46783-Alpha-Globulins,
pubmed-meshheading:46783-Bile Duct Neoplasms,
pubmed-meshheading:46783-Carcinoma, Hepatocellular,
pubmed-meshheading:46783-Colonic Neoplasms,
pubmed-meshheading:46783-Esophageal Neoplasms,
pubmed-meshheading:46783-Female,
pubmed-meshheading:46783-Fetal Proteins,
pubmed-meshheading:46783-Gastrointestinal Diseases,
pubmed-meshheading:46783-Gastrointestinal Neoplasms,
pubmed-meshheading:46783-Humans,
pubmed-meshheading:46783-Liver Neoplasms,
pubmed-meshheading:46783-Male,
pubmed-meshheading:46783-Middle Aged,
pubmed-meshheading:46783-Pancreatic Neoplasms,
pubmed-meshheading:46783-Rectal Neoplasms,
pubmed-meshheading:46783-Stomach Neoplasms
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pubmed:year |
1975
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pubmed:articleTitle |
Serum alpha-fetoprotein in patients with neoplasms of the gastrointestinal tract.
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, U.S. Gov't, P.H.S.
|