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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
1
|
pubmed:dateCreated |
1979-9-17
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pubmed:abstractText |
The action of ergometrine on contractile force of guinea-pig isolated heart was investigated and the effect of receptor antagonists on the inotropic effect of ergometrine, isoproterenol, dopamine and histamine was evaluated. Ergometrine was found to have a good dose-dependent inotropic effect and the antagonism of cimetidine toward this action is reported. Experiments carried out in hearts in which a massive depletion of mast-cells histamine was produced are in favour of a direct action of the drug on H2-receptors.
|
pubmed:language |
eng
|
pubmed:journal | |
pubmed:citationSubset |
IM
|
pubmed:chemical | |
pubmed:status |
MEDLINE
|
pubmed:month |
Apr
|
pubmed:issn |
0065-4299
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pubmed:author | |
pubmed:issnType |
Print
|
pubmed:volume |
9
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
15-7
|
pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:463688-Animals,
pubmed-meshheading:463688-Cimetidine,
pubmed-meshheading:463688-Dose-Response Relationship, Drug,
pubmed-meshheading:463688-Drug Interactions,
pubmed-meshheading:463688-Ergonovine,
pubmed-meshheading:463688-Female,
pubmed-meshheading:463688-Guanidines,
pubmed-meshheading:463688-Guinea Pigs,
pubmed-meshheading:463688-Male,
pubmed-meshheading:463688-Myocardial Contraction,
pubmed-meshheading:463688-Receptors, Histamine H2
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pubmed:year |
1979
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pubmed:articleTitle |
Effect of ergometrine on contractile force of guinea-pig isolated heart: antagonism by cimetidine.
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pubmed:publicationType |
Journal Article,
In Vitro
|