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rdf:type |
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lifeskim:mentions |
umls-concept:C0003241,
umls-concept:C0020852,
umls-concept:C0021311,
umls-concept:C0026809,
umls-concept:C0033809,
umls-concept:C0178539,
umls-concept:C0683598,
umls-concept:C1516240,
umls-concept:C1517004,
umls-concept:C1521761,
umls-concept:C1880177
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pubmed:issue |
5
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pubmed:dateCreated |
1973-2-2
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pubmed:abstractText |
The opsonic, agglutinative, and mouse protective capacities of anti-Pseudomonas antibodies in immune and normal human immunoglobulin G (IgG) preparations were investigated. Opsonic activities of the immune IgG preparations correlated well with their protective activities. Antibodies present in normal IgG showed a substantial agglutinative activity but were poorly protective. Anti-Pseudomonas antibodies of both normal and immune IgG preparations were directed against the same serotype antigen as demonstrated by absorption experiments. Immune anti-Pseudomonas IgG antibodies fixed complement very efficiently as demonstrated by opsonophagocytic and hemolytic tests. Natural anti-Pseudomonas IgG antibodies fixed complement very poorly although they promoted phagocytic killing of bacteria only in the presence of heat-labile serum factors. It was concluded that, although agglutination can be used for qualitative measurement of antibacterial antibodies, it fails to measure their functional capacities.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/4629252-13062052,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4629252-13262900,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4629252-13707611,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4629252-13762792,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4629252-13770916,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4629252-14392118,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4629252-15776568,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4629252-16557861,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4629252-16557946,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4629252-4158592,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4629252-4162743,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4629252-4956109,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4629252-4977486,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4629252-5001942,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4629252-5005303
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
0019-9567
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
5
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
775-82
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pubmed:dateRevised |
2010-9-13
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pubmed:meshHeading |
pubmed-meshheading:4629252-Animals,
pubmed-meshheading:4629252-Antibodies, Bacterial,
pubmed-meshheading:4629252-Antibody Specificity,
pubmed-meshheading:4629252-Blood Bactericidal Activity,
pubmed-meshheading:4629252-Cell Survival,
pubmed-meshheading:4629252-Complement Fixation Tests,
pubmed-meshheading:4629252-Hemadsorption,
pubmed-meshheading:4629252-Hemagglutination Tests,
pubmed-meshheading:4629252-Hemolysis,
pubmed-meshheading:4629252-Hot Temperature,
pubmed-meshheading:4629252-Immunity,
pubmed-meshheading:4629252-Immunoglobulin G,
pubmed-meshheading:4629252-Leukocyte Count,
pubmed-meshheading:4629252-Macrophages,
pubmed-meshheading:4629252-Mice,
pubmed-meshheading:4629252-Mice, Inbred Strains,
pubmed-meshheading:4629252-Opsonin Proteins,
pubmed-meshheading:4629252-Phagocytosis,
pubmed-meshheading:4629252-Pseudomonas Infections,
pubmed-meshheading:4629252-Pseudomonas aeruginosa
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pubmed:year |
1972
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pubmed:articleTitle |
Contribution of humoral and cellular factors to the resistance to experimental infection by Pseudomonas aeruginosa in mice. II. Opsonic, agglutinative, and protective capacities of immunoglobulin G anti-Pseudomonas antibodies.
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pubmed:publicationType |
Journal Article
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