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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
3
|
| pubmed:dateCreated |
1974-7-18
|
| pubmed:abstractText |
Spontaneous mutants of Candida albicans resistant to 5-fluorocytosine (5-FC) were isolated from a strain susceptible to 5-FC. These mutants were compared with 5-FC-resistant strains of C. albicans and Torulopsis glabrata isolated from patients treated with the drug and from untreated patients. Resistance to 5-FC was in all cases followed by a decreased susceptibility to 5-fluorouracil. Most strains were also more resistant to 5-fluorouridine and had a lowered incorporation of uridine. In one spontaneous mutant totally resistant to all three 5-fluoropyrimidines, the uridine monophosphate pyrophosphorylase activity was greatly decreased. The 5-FC-resistant strains were of two main phenotypic classes. Class one was unaffected by 5-FC at the highest concentration tested. The growth rate of strains belonging to the other class was markedly decreased by low concentrations of 5-FC, but these strains were still able to form colonies after 7 days of incubation on plates containing very high concentrations of the drug (2,000 mug/ml). The frequency of spontaneous mutation of a susceptible strain to 5-FC resistance was fairly high. The number of mutants growing on media containing 5-FC was unchanged by concentrations ranging from 25 to 500 mug/ml.
|
| pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/4597703-13278318,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4597703-13418758,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4597703-14888646,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4597703-14907713,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4597703-16557866,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4597703-4311780,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4597703-4560535,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4597703-4919542,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4597703-4986625,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4597703-5429721,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4597703-5955812
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Sep
|
| pubmed:issn |
0066-4804
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
2
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
114-21
|
| pubmed:dateRevised |
2010-9-10
|
| pubmed:meshHeading | |
| pubmed:year |
1972
|
| pubmed:articleTitle |
In vitro studies of 5-fluorocytosine resistance in Candida albicans and Torulopsis glabrata.
|
| pubmed:publicationType |
Journal Article
|