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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
1
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pubmed:dateCreated |
1979-9-17
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pubmed:abstractText |
The red cell indices and results of globin chain synthesis in peripheral blood of obligate beta 0 thalassemia (beta 0 thal) carriers (parents of homozygous beta 0 thal children) and beta thalassemia (beta thal) carriers identified during mass screening are reported. Red cell indices were similar in obligate beta 0 carriers and in carriers diagnosed during mass screening. However there was a higher incidence of anemia in female obligate beta 0 thal carriers. In Sardinia the beta 0 thal carrier showed the usual hematological characteristics of the high Hb A2 beta thal carrier with microcytosis, hypochromia, reduced osmotic fragility; Hb F greater than 1% was found in 30% of the carriers. With MCV, MCH, osmotic fragility test (OFT) and Shine and Lal discriminant function we found 3.5%, 1.5%, 3.5% and 4.0% respectively false negatives in carrier identification. A part from one subject, all obligate carriers had elevated Hb A2 levels. The alpha/beta ratio in obligate carriers (mean +/- SD) was 1.83 +/- 0.26 (N = 30).
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:issn |
0363-0269
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
3
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
33-46
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pubmed:dateRevised |
2004-11-17
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pubmed:meshHeading |
pubmed-meshheading:457422-Adolescent,
pubmed-meshheading:457422-Adult,
pubmed-meshheading:457422-Female,
pubmed-meshheading:457422-Fetal Hemoglobin,
pubmed-meshheading:457422-Hemoglobin A,
pubmed-meshheading:457422-Hemoglobins,
pubmed-meshheading:457422-Heterozygote Detection,
pubmed-meshheading:457422-Humans,
pubmed-meshheading:457422-Iron,
pubmed-meshheading:457422-Italy,
pubmed-meshheading:457422-Male,
pubmed-meshheading:457422-Middle Aged,
pubmed-meshheading:457422-Osmotic Fragility,
pubmed-meshheading:457422-Thalassemia
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pubmed:year |
1979
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pubmed:articleTitle |
Beta 0 thalassemia trait in Sardinia.
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pubmed:publicationType |
Journal Article
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