Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
1972-7-20
pubmed:abstractText
In its first round of replication, the T7 chromosome follows a simple pattern, as viewed in the electron microscope. The iniation of DNA synthesis occurs about 17% from the genetic left end of the viral DNA rod. Bidirectional DNA synthesis from this origin then generates a replicating intermediate that we call an "eye form." In the eye form, when synthesis in the leftward direction reaches the left end of the viral chromosome, the molecule is converted into a Y-shaped replicating rod. The remaining growing point continues synthesis rightward, until presumably it runs off the right end of the DNA rod, thus terminating replication. Numerous T7 chromosomes were found in which a second round of replication had begun before the first round had finished. Analysis of these reinitiated DNA molecules showed that the second round of replication, like the first, began 17% from the end of the chromosome and involved bidirectional DNA synthesis.
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/4554539-16590258, http://linkedlifedata.com/resource/pubmed/commentcorrection/4554539-4312123, http://linkedlifedata.com/resource/pubmed/commentcorrection/4554539-4330296, http://linkedlifedata.com/resource/pubmed/commentcorrection/4554539-4331651, http://linkedlifedata.com/resource/pubmed/commentcorrection/4554539-4332795, http://linkedlifedata.com/resource/pubmed/commentcorrection/4554539-4550513, http://linkedlifedata.com/resource/pubmed/commentcorrection/4554539-4551146, http://linkedlifedata.com/resource/pubmed/commentcorrection/4554539-4891987, http://linkedlifedata.com/resource/pubmed/commentcorrection/4554539-4937091, http://linkedlifedata.com/resource/pubmed/commentcorrection/4554539-4941987, http://linkedlifedata.com/resource/pubmed/commentcorrection/4554539-4942327, http://linkedlifedata.com/resource/pubmed/commentcorrection/4554539-4943552, http://linkedlifedata.com/resource/pubmed/commentcorrection/4554539-5001611, http://linkedlifedata.com/resource/pubmed/commentcorrection/4554539-5243927, http://linkedlifedata.com/resource/pubmed/commentcorrection/4554539-5244753, http://linkedlifedata.com/resource/pubmed/commentcorrection/4554539-5263754, http://linkedlifedata.com/resource/pubmed/commentcorrection/4554539-5289384, http://linkedlifedata.com/resource/pubmed/commentcorrection/4554539-5481280, http://linkedlifedata.com/resource/pubmed/commentcorrection/4554539-5689363, http://linkedlifedata.com/resource/pubmed/commentcorrection/4554539-6031715
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Apr
pubmed:issn
0027-8424
pubmed:author
pubmed:issnType
Print
pubmed:volume
69
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
998-1002
pubmed:dateRevised
2009-11-18
pubmed:meshHeading
pubmed:year
1972
pubmed:articleTitle
Initiation and reinitiation of DNA synthesis during replication of bacteriophage T7.
pubmed:publicationType
Journal Article