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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
1973-10-15
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pubmed:abstractText |
Sprague-Dawley rats have a marked age-related susceptibility to Haemophilus influenzae type b that does not correlate with serum bactericidal activity. Eighty percent of 5-day-old animals that survive to 48 h after an intraperitoneal inoculation of a mean lethal dose of bacteria have histologically documented meningitis. Animals surviving the inoculations as infants manifest cerebral dysfunction as adults. This model should facilitate experimental study of bacterial meningitis.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/4542033-13242852,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4542033-13563465,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4542033-13832011,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4542033-13853365,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4542033-13939300,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4542033-14158895,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4542033-14200773,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4542033-14263639,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4542033-14400091,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4542033-14485753,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4542033-4536614,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4542033-4998474
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
0019-9567
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
8
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
278-90
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:4542033-Age Factors,
pubmed-meshheading:4542033-Animals,
pubmed-meshheading:4542033-Animals, Newborn,
pubmed-meshheading:4542033-Blood Bactericidal Activity,
pubmed-meshheading:4542033-Brain,
pubmed-meshheading:4542033-DNA,
pubmed-meshheading:4542033-Haemophilus influenzae,
pubmed-meshheading:4542033-Immunity,
pubmed-meshheading:4542033-Injections, Intraperitoneal,
pubmed-meshheading:4542033-Intestines,
pubmed-meshheading:4542033-Lethal Dose 50,
pubmed-meshheading:4542033-Liver,
pubmed-meshheading:4542033-Lung,
pubmed-meshheading:4542033-Meningitis, Haemophilus,
pubmed-meshheading:4542033-Rats,
pubmed-meshheading:4542033-Remission, Spontaneous,
pubmed-meshheading:4542033-Skull,
pubmed-meshheading:4542033-Spleen
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pubmed:year |
1973
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pubmed:articleTitle |
Production of Haemophilus influenzae b meningitis in infant rats by intraperitoneal inoculation.
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pubmed:publicationType |
Journal Article
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