Linked Life Data

444541

Source:http://linkedlifedata.com/resource/pubmed/id/444541

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1979-8-16
pubmed:abstractText
The present study describes the (xanthine:NAD+ oxidoreductase, EC 1.2.1.37) synthesis and degradation of chick liver xanthine dehydrogenase in vivo and in organ cultures. The results indicate that control of xanthine dehydrogenase activity is mediated by changes in the rate of enzyme synthesis, but that degradation rates are unaffected. The results also suggest that xanthine dehydrogenase synthesis occurs through a previously unreported intermediate. Detected in cultures of liver tissue, this intermediate apparently is not converted into an active enzyme. A model of synthesis and degradation for xanthine dehydrogenase proposes that the synthesis of the enzyme is proportional to messenger RNA and includes an inactive enzyme precursor and a second inactive intermediate prior to degradation. Integrated mathematical solutions describing the concentration of intermediates as a function of time can be found explicitly for simple models. The appendix to this paper extrapolates solutions for one-, two- and three-step models to generate a mathematical solution for an 'n'-step model containing 'n' intermediates. The rate constants in the solutions can be found experimentally.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
May
pubmed:issn
0006-3002
pubmed:author
pubmed:issnType
Print
pubmed:day
10
pubmed:volume
568
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
157-76
pubmed:dateRevised
2007-11-15
pubmed:meshHeading
pubmed:year
1979
pubmed:articleTitle
Synthesis and degradation of xanthine dehydrogenase in chick liver. In vivo and in vitro studies.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, U.S. Gov't, Non-P.H.S.