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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
2
|
pubmed:dateCreated |
1979-7-16
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pubmed:abstractText |
The uptake of adenine and hypoxanthine in HGPRT-deficient and normal human erythrocytes was measured using a rapid filtering centrifugation technique. The transport of hypoxanthine as well as of adenine is impaired in the mutant cells. The transport of hypoxanthine into HGPRT-deficient erythrocytes differs from that into normal cells with respect to a higher accumulation capacity, to lower initial velocities and to the kinetic properties of the translocator. In addition, a higher accumulation capacity and lower initial velocities of adenine uptake could be demonstrated in mutant cells. A linkage of the purine translocator with purine phosphoribosyltransferases associated with the erythrocyte membrane is discussed.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
|
pubmed:issn |
0001-5652
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pubmed:author | |
pubmed:issnType |
Print
|
pubmed:volume |
29
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
118-23
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pubmed:dateRevised |
2004-11-17
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pubmed:meshHeading |
pubmed-meshheading:437792-Adenine,
pubmed-meshheading:437792-Erythrocytes,
pubmed-meshheading:437792-Gout,
pubmed-meshheading:437792-Humans,
pubmed-meshheading:437792-Hypoxanthine Phosphoribosyltransferase,
pubmed-meshheading:437792-Hypoxanthines,
pubmed-meshheading:437792-Lesch-Nyhan Syndrome,
pubmed-meshheading:437792-Mutation,
pubmed-meshheading:437792-Time Factors
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pubmed:year |
1979
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pubmed:articleTitle |
Purine base transport in normal and mutant erythrocytes.
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pubmed:publicationType |
Journal Article
|