Linked Life Data

42868

Source:http://linkedlifedata.com/resource/pubmed/id/42868

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1980-3-17
pubmed:abstractText
Cutaneous hyper-irritability was produced in the trigeminal sensory distribution of chronically prepared rats by injecting various central stimulants into the dorsal subarachnoid space overlying caudal medulla. Effective substances were classified into three groups according to the behavioral patterns induced. These were (1) picrotoxin and penicillin G-K, (2) strychnine and brucine, and (3) D,L-homocysteic acid. Of these substances, picrotoxin was the most effective. The hyper-irritability elicited by picrotoxin or penicillin G-K was associated with a relatively localized trigger zone in the face, while that elicited by strychnine or brucine spread beyond the trigeminal region to the first cervical dermatome. D,L-homocysteic acid evoked only spontaneous scratching and vocalization. Picrotoxin-induced hyper-irritability involved facilitation of impulse transmission from cutaneous afferent terminals to second-order neurons in the trigeminal nucleus caudalis.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Oct
pubmed:issn
0304-3959
pubmed:author
pubmed:issnType
Print
pubmed:volume
7
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
147-57
pubmed:dateRevised
2003-11-14
pubmed:meshHeading
pubmed:year
1979
pubmed:articleTitle
An experimental model of hyper-irritability in the trigeminal skin field of the rat.
pubmed:publicationType
Journal Article