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pubmed-article:426503pubmed:abstractTextAmoxicillin pharmacokinetics after intravenous administration were studied in patients with normal renal function, with impaired renal function, and during hemodialysis. The average urinary recovery was 68% in patients with normal renal function. Serum half-life was highly correlated (r = 0.967) with creatinine clearance corrected for body weight. Expected half-life was 71 min for a corrected creatinine clearance of 100 ml/min per 70 kg and 16 h in the anephric patient. Average amoxicillin half-life on hemodialysis was 3.6 h. We present a dosage nomogram for making appropriate adjustments to loading dose based on patient weight and maintenance dose based on corrected creatinine clearance.lld:pubmed
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pubmed-article:426503pubmed:dateRevised2009-11-18lld:pubmed
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pubmed-article:426503pubmed:articleTitlePharmacokinetics of amoxicillin: Dosage nomogram for patients with impaired renal function.lld:pubmed
pubmed-article:426503pubmed:publicationTypeJournal Articlelld:pubmed