|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
1
|
|
pubmed:dateCreated |
1979-5-26
|
|
pubmed:abstractText |
Amoxicillin pharmacokinetics after intravenous administration were studied in patients with normal renal function, with impaired renal function, and during hemodialysis. The average urinary recovery was 68% in patients with normal renal function. Serum half-life was highly correlated (r = 0.967) with creatinine clearance corrected for body weight. Expected half-life was 71 min for a corrected creatinine clearance of 100 ml/min per 70 kg and 16 h in the anephric patient. Average amoxicillin half-life on hemodialysis was 3.6 h. We present a dosage nomogram for making appropriate adjustments to loading dose based on patient weight and maintenance dose based on corrected creatinine clearance.
|
|
pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/426503-1003329,
http://linkedlifedata.com/resource/pubmed/commentcorrection/426503-1094950,
http://linkedlifedata.com/resource/pubmed/commentcorrection/426503-1115440,
http://linkedlifedata.com/resource/pubmed/commentcorrection/426503-13454105,
http://linkedlifedata.com/resource/pubmed/commentcorrection/426503-4345622,
http://linkedlifedata.com/resource/pubmed/commentcorrection/426503-4433471,
http://linkedlifedata.com/resource/pubmed/commentcorrection/426503-4618910,
http://linkedlifedata.com/resource/pubmed/commentcorrection/426503-5316403,
http://linkedlifedata.com/resource/pubmed/commentcorrection/426503-836010,
http://linkedlifedata.com/resource/pubmed/commentcorrection/426503-842999,
http://linkedlifedata.com/resource/pubmed/commentcorrection/426503-942138
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Jan
|
|
pubmed:issn |
0066-4804
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:volume |
15
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
28-33
|
|
pubmed:dateRevised |
2009-11-18
|
|
pubmed:meshHeading |
|
|
pubmed:year |
1979
|
|
pubmed:articleTitle |
Pharmacokinetics of amoxicillin: Dosage nomogram for patients with impaired renal function.
|
|
pubmed:publicationType |
Journal Article
|
