Linked Life Data

4192568

Source:http://linkedlifedata.com/resource/pubmed/id/4192568

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6
pubmed:dateCreated
1970-7-23
pubmed:abstractText
Congenic mice, differing genetically only at the loci coding for immunoglobulin H chain (or Fc) structures, have been used to study cell interactions in the 7S (gammaG(2a)) antibody response to sheep erythrocytes (SRBC), as detected by the Jerne plaque-forming cell (PFC) method. The interaction between thymus and bone marrow cells was studied in adult thymectomized irradiated recipients, protected with syngeneic bone marrow and injected with thymus cells from the partner congenic strain. All of the gammaG(2a) PFC detected in the spleens of these mice were of bone marrow allotype. Adoptive secondary immune responses were then studied to determine whether a similar interaction between memory cells and bone marrow derived cells could be detected. Primed spleen cells from the partner congenic strain, or a subpopulation of these cells obtained by BSA density gradient fractionation, were injected into irradiated recipients alone, or together with syngeneic nonimmune spleen or bone marrow cells. All gammaG(2a) PFC detected in these experiments were of primed cell allotype. There was no evidence that antibody forming cell precursors in normal spleen or bone marrow participate in the adoptive secondary immune response detected 7 days after transfer of primed spleen cells. This was true regardless of whether the bone marrow cells were injected at the time of transfer, or were injected 1-2 wk earlier and allowed to become established in the spleens of recipient mice. Although no specific cell interaction was seen, bone marrow (and, to a lesser degree, normal spleen) cells were found to have a nonspecific enhancing effect on the adoptive secondary response when they were injected together with the primed spleen cells. This enhancement was not evident if the bone marrow cells were injected 1 or 2 wk prior to primed cell transfer.
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/4192568-13945311, http://linkedlifedata.com/resource/pubmed/commentcorrection/4192568-14071261, http://linkedlifedata.com/resource/pubmed/commentcorrection/4192568-14214095, http://linkedlifedata.com/resource/pubmed/commentcorrection/4192568-19867303, http://linkedlifedata.com/resource/pubmed/commentcorrection/4192568-4160097, http://linkedlifedata.com/resource/pubmed/commentcorrection/4192568-4192567, http://linkedlifedata.com/resource/pubmed/commentcorrection/4192568-4958328, http://linkedlifedata.com/resource/pubmed/commentcorrection/4192568-5333748, http://linkedlifedata.com/resource/pubmed/commentcorrection/4192568-5645218, http://linkedlifedata.com/resource/pubmed/commentcorrection/4192568-5691985, http://linkedlifedata.com/resource/pubmed/commentcorrection/4192568-5691986, http://linkedlifedata.com/resource/pubmed/commentcorrection/4192568-5791605, http://linkedlifedata.com/resource/pubmed/commentcorrection/4192568-5870100, http://linkedlifedata.com/resource/pubmed/commentcorrection/4192568-5967867, http://linkedlifedata.com/resource/pubmed/commentcorrection/4192568-6034749, http://linkedlifedata.com/resource/pubmed/commentcorrection/4192568-6082735
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
AIM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
0022-1007
pubmed:author
pubmed:issnType
Print
pubmed:day
1
pubmed:volume
131
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1109-20
pubmed:dateRevised
2010-9-13
pubmed:meshHeading
pubmed:year
1970
pubmed:articleTitle
Immunological memory in mice. II. Cell interactions in the secondary immune response studies by means of immunoglobulin allotype markers.
pubmed:publicationType
Journal Article