Linked Life Data

410749

Source:http://linkedlifedata.com/resource/pubmed/id/410749

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
1977-12-29
pubmed:abstractText
Among the four hypothalamic-releasing hormones (TRH, SRIF, LHRH, and MIF) with central nervous system actions and possibly with psychotropic properties, TRH is the one most systematically studied. Animal pharmacological data has confirmed the activity of TRH as a centrally acting agent with a widespread neurophysiological role independent of the pituitary-thyroid axis; and human pharmacological studies revealed that the computer EEG profile of TRH resembles psychostimulant drugs and secondary amine tricyclic antidepressants. Corresponding with this are the clinical findings that TRH produces a rapid but transient improvement in unipolar depression in women, a sense of increased energy and well-being, or increase of interest, desire and drive for work, food, and sex. In spite of the equivocal findings in some of the clinical studies, a recent investigation raised the possibility that a transient favorable response to TRH may identify a patient population responsive to maprotilline, or other norepinephrine uptake inhibitors.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0020-8272
pubmed:author
pubmed:issnType
Print
pubmed:volume
12
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
166-73
pubmed:dateRevised
2009-11-11
pubmed:meshHeading
pubmed:year
1977
pubmed:articleTitle
TRH in depressive illness.
pubmed:publicationType
Journal Article, Clinical Trial