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pubmed:abstractText |
Virus-containing allantoic fluid (VCAF) serves as raw material for influenza virus manufacture in the USSR. VCAF composition varies greatly from batch to batch. The causes of instability of its composition were studied. The main high molecular admixtures determining VCAF instability were found to include proteins and lipids getting into VCAF with amniotic fluid, blood, and yolk of the embryo when VCAF is collected. Physicochemical characteristics (pH, protein and lipid concentrations, protein composition) for VCAF control at pooling are proposed.
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