Linked Life Data

4071600

Source:http://linkedlifedata.com/resource/pubmed/id/4071600

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6
pubmed:dateCreated
1985-12-24
pubmed:abstractText
Currently, platelet concentrates are stored in 50 to 60 ml of plasma. A major drawback to storage in plasma is the considerable loss of platelet function which occurs during storage. A modified Tyrodes medium has been developed for storage of platelets. A comparison between platelet concentrates stored in this medium and in plasma showed that platelet aggregation and release responses to synergistic pairs of stimuli were equivalent for both types of concentrates on the day of preparation and after 72 hours. Platelet aggregation and release responses to single stimuli, the content of membrane glycoproteins, and the pH declined during storage but were similar for both preparations. The data show that plasma is not required to maintain in vitro platelet function during storage of platelet concentrates, but in vivo functions remain to be determined. The use of an artificial medium has the advantages of decreasing patient exposure to plasma contaminants, generating additional plasma for fractionation, and controlling more exactly the storage environment.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0041-1132
pubmed:author
pubmed:issnType
Print
pubmed:volume
25
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
551-6
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:articleTitle
Platelet storage in a plasma-free medium.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't