Linked Life Data

4069122

Source:http://linkedlifedata.com/resource/pubmed/id/4069122

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
1985-12-31
pubmed:abstractText
BDF1 mice injected with methylnitrosourea (MNU, 50 mg/kg) developed T cell leukemias within 9-35 weeks (median induction time 18 weeks). Leukemic cells, determined by transplantation, were found 2-5 weeks before the death of the animals. Natural killer (NK) cell activity in the spleen and peritoneal exudate cells was studied using YAC-1 cells as targets. MNU-treated mice showed reduced lytic activity with or without stimulation by Corynebacterium parvum. NK activity was essentially the same in mice with and without transplantable leukemic cells. No correlation could be demonstrated between the degree of NK cell depression, as studied in the spleen after splenectomy, and the survival time of individual mice.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0254-7600
pubmed:author
pubmed:issnType
Print
pubmed:volume
4
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
193-201
pubmed:dateRevised
2003-11-14
pubmed:meshHeading
pubmed:year
1985
pubmed:articleTitle
Leukemogenesis by methylnitrosourea in BDF1 mice. The origin of transplantable cells and the activity of the natural killer cells during the preleukemic period.
pubmed:publicationType
Journal Article