Linked Life Data

4045821

Source:http://linkedlifedata.com/resource/pubmed/id/4045821

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1985-10-31
pubmed:abstractText
Collagenase-dispersed theca cells from the 3rd and 4th largest ovarian follicles (T3) were responsive to LH stimulation of both oestrogen and androstenedione production, whereas theca cells from the largest follicle (T1) failed to respond to the gonadotrophin stimulation. Similarly, 8-bromo cAMP and forskolin were more effective in stimulating oestrogen and androstenedione production in T3 than in T1 cells, indicating that post-receptor events were involved in the decreased LH responsiveness of T1 cells. The C17-20-lyase activity, as measured by conversion of [3H]17-hydroxyprogesterone to androstenedione, was greatly reduced in T1 cells as compared to T3 cells. The results demonstrate that a decrease in C17-20-lyase activity, in addition to a decrease in aromatase activity, contributes to the loss of LH-stimulated steroidogenesis in mature theca cells.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jul
pubmed:issn
0022-4251
pubmed:author
pubmed:issnType
Print
pubmed:volume
74
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
543-50
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1985
pubmed:articleTitle
Decreased androstenedione production with increased follicular maturation in theca cells from the domestic hen (Gallus domesticus).
pubmed:publicationType
Journal Article, Comparative Study, Research Support, U.S. Gov't, P.H.S.