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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
2
|
pubmed:dateCreated |
1985-11-14
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pubmed:abstractText |
The effects of enantiomers of nomifensine were compared in five psychopharmacological tests in which (+/-)-nomifensine is active. In mice, (+)-nomifensine increased motor activity at 16 mg/kg, 8 mg/kg reduced the hypothermia and ptosis induced by reserpine and antagonized the hypothermia induced by 16 mg/kg of apomorphine. (+)-Nomifensine 4 mg/kg potentiated yohimbine toxicity. (-)-Nomifensine 4,8, or 16 mg/kg was inactive in all these tests. In rats, (+)-nomifensine 8 mg/kg induced stereotyped movements whereas (-)-nomifensine 64 mg/kg did not produce stereotypies.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
0014-2999
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:day |
17
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pubmed:volume |
113
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
271-4
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:4043212-Animals,
pubmed-meshheading:4043212-Apomorphine,
pubmed-meshheading:4043212-Male,
pubmed-meshheading:4043212-Mice,
pubmed-meshheading:4043212-Mice, Inbred Strains,
pubmed-meshheading:4043212-Motor Activity,
pubmed-meshheading:4043212-Nomifensine,
pubmed-meshheading:4043212-Rats,
pubmed-meshheading:4043212-Rats, Inbred Strains,
pubmed-meshheading:4043212-Reserpine,
pubmed-meshheading:4043212-Stereoisomerism,
pubmed-meshheading:4043212-Stereotyped Behavior,
pubmed-meshheading:4043212-Yohimbine
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pubmed:year |
1985
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pubmed:articleTitle |
Psychopharmacological effects of nomifensine enantiomers.
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pubmed:publicationType |
Journal Article,
Comparative Study
|