Linked Life Data

4039955

Source:http://linkedlifedata.com/resource/pubmed/id/4039955

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
1985-8-12
pubmed:abstractText
The factors that control the rate of granulosa cell proliferation during follicular development are unknown. The object of this study was to test the hypothesis that growth rates of small and medium follicles may be modulated by cyclic alterations in endogenous hormone concentrations. Follicular growth in adult cycling rats was compared with hypophysectomized rats, untreated prepubertal rats, and prepubertal rats treated with exogenous gonadotropins. Cell kinetics was studied using a metaphase arrest technique and by long-term infusion of [3H]thymidine. Many follicles of hypophysectomized rats showed evidence of continued cell proliferation despite the absence of gonadotropins. In hypophysectomized rats, follicular growth was able to proceed to the size of the largest healthy non-preovulatory follicles in the proestrous rat ovary. Follicular growth in prepubertal rats progressed little beyond this same size range. Granulosa cell proliferation rates differed in immature rats and cycling rats. Granulosa cells in small follicles (80-180 cells in the largest cross-section) of cycling rats grew slowly. However, granulosa cells in small follicles of immature rats were among the fastest growing in the ovary. These results suggest that, although gonadotropins are not absolutely required to maintain granulosa cell proliferation in small follicles, the rate at which these follicles grow varies under different hormonal conditions.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
May
pubmed:issn
0006-3363
pubmed:author
pubmed:issnType
Print
pubmed:volume
32
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
979-87
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1985
pubmed:articleTitle
Comparison of granulosa cell proliferation in small follicles of hypophysectomized, prepubertal, and mature rats.
pubmed:publicationType
Journal Article, Comparative Study, Research Support, U.S. Gov't, P.H.S.