Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1985-10-21
pubmed:abstractText
Primary sclerosing cholangitis (PSC) is an uncommon, chronic disorder characterized by inflammatory fibrosis usually involving the entire biliary tree. The etiology has been unknown, but PSC is closely associated with ulcerative colitis, which coexists in more than two thirds of patients with PSC. In recent studies 3% to 5% of all patients with ulcerative colitis had PSC. We propose that PSC is, at least in part, an immunologically mediated disease; it is closely associated with human leckocyte antigens B8 and DR3, and circulating autoantibodies to colon and portal tract are frequently present. The anticolon antibody cross-reacts with enteric Escherichia coli. The disease may possibly be triggered in susceptible patients with ulcerative colitis by immunization with antigens shared between enteric microorganisms and the biliary system.
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/4036118-1274936, http://linkedlifedata.com/resource/pubmed/commentcorrection/4036118-13873212, http://linkedlifedata.com/resource/pubmed/commentcorrection/4036118-14015587, http://linkedlifedata.com/resource/pubmed/commentcorrection/4036118-14067906, http://linkedlifedata.com/resource/pubmed/commentcorrection/4036118-14141789, http://linkedlifedata.com/resource/pubmed/commentcorrection/4036118-348130, http://linkedlifedata.com/resource/pubmed/commentcorrection/4036118-363225, http://linkedlifedata.com/resource/pubmed/commentcorrection/4036118-4130311, http://linkedlifedata.com/resource/pubmed/commentcorrection/4036118-437430, http://linkedlifedata.com/resource/pubmed/commentcorrection/4036118-5322083, http://linkedlifedata.com/resource/pubmed/commentcorrection/4036118-5901372, http://linkedlifedata.com/resource/pubmed/commentcorrection/4036118-6057772, http://linkedlifedata.com/resource/pubmed/commentcorrection/4036118-6226227, http://linkedlifedata.com/resource/pubmed/commentcorrection/4036118-6618106, http://linkedlifedata.com/resource/pubmed/commentcorrection/4036118-6657913, http://linkedlifedata.com/resource/pubmed/commentcorrection/4036118-6832707, http://linkedlifedata.com/resource/pubmed/commentcorrection/4036118-6888429, http://linkedlifedata.com/resource/pubmed/commentcorrection/4036118-6969363, http://linkedlifedata.com/resource/pubmed/commentcorrection/4036118-6982501, http://linkedlifedata.com/resource/pubmed/commentcorrection/4036118-7001237, http://linkedlifedata.com/resource/pubmed/commentcorrection/4036118-7002433, http://linkedlifedata.com/resource/pubmed/commentcorrection/4036118-7209379, http://linkedlifedata.com/resource/pubmed/commentcorrection/4036118-7227776, http://linkedlifedata.com/resource/pubmed/commentcorrection/4036118-7308996, http://linkedlifedata.com/resource/pubmed/commentcorrection/4036118-7372059, http://linkedlifedata.com/resource/pubmed/commentcorrection/4036118-7399227, http://linkedlifedata.com/resource/pubmed/commentcorrection/4036118-7421127, http://linkedlifedata.com/resource/pubmed/commentcorrection/4036118-7429307, http://linkedlifedata.com/resource/pubmed/commentcorrection/4036118-7439807, http://linkedlifedata.com/resource/pubmed/commentcorrection/4036118-913913
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:month
Aug
pubmed:issn
0093-0415
pubmed:author
pubmed:issnType
Print
pubmed:volume
143
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
193-5
pubmed:dateRevised
2009-11-18
pubmed:meshHeading
pubmed:year
1985
pubmed:articleTitle
Primary sclerosing cholangitis--an immunologically mediated disease?
pubmed:publicationType
Journal Article