Linked Life Data

4028005

Source:http://linkedlifedata.com/resource/pubmed/id/4028005

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
9
pubmed:dateCreated
1985-9-30
pubmed:abstractText
The effect of hypothermia on cell survival and on subsequent response to hyperthermia was studied in asynchronous and synchronized Neuro-2A cells. Cell cycle progression was blocked at temperatures below 27 degrees C. Immediately after shift to hypothermic temperatures, cells became more sensitive to hyperthermia. Development of thermosensitization was time and temperature dependent. Thermosensitization of cells by hypothermia was high at 0 degrees C and 15 degrees-30 degrees C and less at 5 degrees-10 degrees C. Sensitization started to occur before hypothermic cell death became manifest and developed gradually. Hypothermic cell death was observed when the cells were incubated for more than 1 day at temperatures of 0 degrees-24 degrees C with a minimal cell death during incubation at 6 degrees C. Thermosensitization of cells by hypothermia depended on the position of the cell in the cell cycle at the time of shift to hypothermic temperatures. Cells in late G1 and early S phase became more thermosensitive than did cells in G1 or late S-G2 phase. Furthermore G1-S cells were more sensitive to prolonged hypothermia alone than were G1 or late S-G2 cells. In contrast, late S-G2 cells were most sensitive to hyperthermia alone. It is concluded that the temperature- and cell cycle-dependent way of hypothermic induced cell death was similar to the thermosensitization of cells by hypothermia. But thermosensitization became manifest prior to the actual cell death, following hypothermic treatment.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Sep
pubmed:issn
0008-5472
pubmed:author
pubmed:issnType
Print
pubmed:volume
45
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
4132-7
pubmed:dateRevised
2008-11-21
pubmed:meshHeading
pubmed:year
1985
pubmed:articleTitle
Cell killing and sensitization to heat shock by hypothermic incubation of asynchronous and synchronized mouse neuroblastoma cells.
pubmed:publicationType
Journal Article