Linked Life Data

4026487

Source:http://linkedlifedata.com/resource/pubmed/id/4026487

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
9
pubmed:dateCreated
1985-9-26
pubmed:abstractText
Lidocaine hydrochloride is commonly infused intravenously to prevent ventricular arrhythmias. In some patients, elevations in serum lidocaine levels can cause serious toxic effects. In a group of 19 patients given a constant infusion of lidocaine, we confirmed the observation that serum lidocaine levels rose significantly between four and 24 hours after initiation of therapy. One of these patients manifested a toxic reaction to lidocaine. The lidocaine infusion rate was modified in a second group of 32 patients on the basis of the four-hour serum level. In these patients, after dosage adjustment, the mean lidocaine level did not rise, and all levels remained within the 2- to 4-mg/L therapeutic range at 24 hours. Without dosage adjustment, half of these levels would have fallen outside the desired range. A simple formula can be used to adjust prophylactic lidocaine infusion rates to attain levels that remain therapeutic, yet nontoxic.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
AIM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Sep
pubmed:issn
0003-9926
pubmed:author
pubmed:issnType
Print
pubmed:volume
145
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1588-91
pubmed:dateRevised
2007-11-15
pubmed:meshHeading
pubmed:year
1985
pubmed:articleTitle
Simple method for maintaining serum lidocaine levels in the therapeutic range.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S.