Linked Life Data

400965

Source:http://linkedlifedata.com/resource/pubmed/id/400965

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1989-9-14
pubmed:abstractText
1. Genetic duplications can give rise to homologous physiological mechanisms that include structurally related protein components. There are many such examples of related proteins within the human body. 2. Evolutionary histories showing the origins and subsequent divergences of these distantly related proteins can be derived from the protein sequences and correlated with the functional characteristics of these proteins. 3. The hormones related to glucagon provide an example of homology of physiological mechanisms and emergence of new functions subsequent to gene duplications. 4. The proteins related to troponin C illustrate the participation of distantly related proteins in the same mechanism (muscle contraction), the relationship of proteins characteristic of a specialized tissue to proteins found in all eukaryote cells, and the correlation of genetic duplications with the evolutionary appearance of different types of muscle.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0305-0491
pubmed:author
pubmed:issnType
Print
pubmed:volume
62
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1-5
pubmed:dateRevised
2010-11-18
pubmed:meshHeading
pubmed:year
1979
pubmed:articleTitle
Evolution of homologous physiological mechanisms based on protein sequence data.
pubmed:affiliation
National Biomedical Research Foundation, Georgetown University Medical Center, Washington, D.C. 20007.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Review