Linked Life Data

4009616

Source:http://linkedlifedata.com/resource/pubmed/id/4009616

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
7
pubmed:dateCreated
1985-8-14
pubmed:abstractText
A series of 6-chloro-2-substituted-9-[[3-(dimethylamino)propyl]amino]acridines has been prepared. The binding affinities and the unwinding angles for the acridine derivatives, relative to ethidium, were determined from viscometric titrations with ccs-DNA. The binding affinities were the same, within experimental error, ca. 2.0 X 10(-5). Similarly, with the exception of 11, the unwinding angles were close to 17 degrees. For 11 the unwinding angle (12 degrees) was smaller than the other derivatives. The general insensitivity of the apparent binding constants to substituent effects is attributable to a masking effect of the formal charge on the ring. The smaller unwinding angle for 11 is believed to arise from its relative dissymmetry, resulting in a "wedge" effect upon intercalation.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jul
pubmed:issn
0022-2623
pubmed:author
pubmed:issnType
Print
pubmed:volume
28
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
940-4
pubmed:dateRevised
2008-11-21
pubmed:meshHeading
pubmed:year
1985
pubmed:articleTitle
The intercalation of 6-chloro-substituted-9-[[3-(dimethylamino)propyl]amino]acridines with DNA.
pubmed:publicationType
Journal Article, Comparative Study, Research Support, U.S. Gov't, Non-P.H.S., Research Support, Non-U.S. Gov't