Linked Life Data

4007283

Source:http://linkedlifedata.com/resource/pubmed/id/4007283

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6
pubmed:dateCreated
1985-8-2
pubmed:abstractText
Autonomic neuropathy occurring in sympathetic nerves of the spontaneously diabetic BB rat has been characterized using ultrastructural and morphometric techniques. Paravertebral thoracic ganglion cells, preganglionic myelinated fibers of the white ramus, and postganglionic unmyelinated fibers of the gray ramus communicans were examined in a longitudinal fashion. The main structural abnormality consisted of expanded axons containing a variety of normal and abnormal subcellular structures, so-called dystrophic axonal changes. These increased with duration of diabetes and were found in close proximity to the somata of ganglion cells, suggesting a preganglionic origin. The ganglion cells showed no alteration in perikaryal or nuclear volume but exhibited decreased number of synapses, which correlated with the progressive increase of dystrophic changes. While no qualitative or quantitative abnormalities could be demonstrated in preganglionic myelinated fibers of the white ramus, postganglionic fibers in the gray ramus showed an increased number of glycogenosomes, axonal sequestration, and reduction in axonal size. The present findings suggest an axonopathy in sympathetic nerves of the diabetic BB rat.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
AIM
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
0012-1797
pubmed:author
pubmed:issnType
Print
pubmed:volume
34
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
558-64
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1985
pubmed:articleTitle
Diabetic autonomic neuropathy in the BB rat. Ultrastructural and morphometric changes in sympathetic nerves.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't