Linked Life Data

3989144

Source:http://linkedlifedata.com/resource/pubmed/id/3989144

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5
pubmed:dateCreated
1985-6-17
pubmed:abstractText
Raised serum IgE levels were found in a high proportion of rats that had been exposed to tobacco smoke twice daily 5 days a week for 8 wk in a Dontenville-type smoking machine. Levels above 1 ng/ml of IgE were found in nine of 20 animals exposed to cigarette smoke and in five of 20 rats exposed to smoke from cigarettes with 1.45% phenylmethyloxidiazole added for possible protection against the effects of the smoke. None of the 20 control rats exhibited similarly increased serum IgE. Exposure to tobacco smoke did not significantly affect the serum concentrations of IgM and IgG. The development of specific IgE and IgG antibodies was also influenced by tobacco smoke exposure. Rats exposed to ovalbumin aerosol developed increased levels of IgG and IgE antibodies, whereas no effect on the development of antibody titers was found in rats immunized by the subcutaneous route. This study demonstrates that exposure to tobacco smoke increases serum IgE levels and enhances sensitization via the airways by a local effect, thus supporting the "mucosal theory of atopy."
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
AIM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
May
pubmed:issn
0091-6749
pubmed:author
pubmed:issnType
Print
pubmed:volume
75
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
594-8
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1985
pubmed:articleTitle
Increased IgE antibody responses in rats exposed to tobacco smoke.
pubmed:publicationType
Journal Article