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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
4
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pubmed:dateCreated |
1985-4-30
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pubmed:abstractText |
The time course of nitrous oxide analgesia was studied in rats with a behavioral criterion, the tail-flick test to radiant heat. All rats were placed individually in a Plexiglas tube and exposed to either nitrous oxide, 75% in oxygen, or room air (control) for 2 hr. Analgesic potency was evaluated by prolongation of the time required to induce tail-flick. Although individual animals showed variability in the tail-flick time during exposure to nitrous oxide, no animal showed a tendency toward the development of tolerance, and a statistically significant sustained prolongation of tail-flick time was produced.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
AIM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
0003-3022
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
62
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
502-4
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:3985406-Analgesics,
pubmed-meshheading:3985406-Animals,
pubmed-meshheading:3985406-Drug Tolerance,
pubmed-meshheading:3985406-Male,
pubmed-meshheading:3985406-Mass Spectrometry,
pubmed-meshheading:3985406-Nitrous Oxide,
pubmed-meshheading:3985406-Oxygen,
pubmed-meshheading:3985406-Rats,
pubmed-meshheading:3985406-Rats, Inbred Strains,
pubmed-meshheading:3985406-Reaction Time,
pubmed-meshheading:3985406-Time Factors
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pubmed:year |
1985
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pubmed:articleTitle |
Acute tolerance to the analgesic action of nitrous oxide does not develop in rats.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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