rdf:type |
|
lifeskim:mentions |
|
pubmed:issue |
2
|
pubmed:dateCreated |
1985-4-26
|
pubmed:abstractText |
DO 710, a benzamide derivative previously shown to display a dopamine antagonistic potency superior to that of sulpiride, was 3H-labeled. Its use as radioligand was assessed in membrane binding and autoradiographic studies. The compound displayed relatively high affinity (Kd 2 nM) and pronounced selectivity for dopamine receptors (distinct from D-1 receptors) as well as low non-specific binding particularly evidenced in autoradiographic experiments. Hence [3H](-)-DO 710 displays distinct technical advantages over commonly used dopaminergic radioligands.
|
pubmed:language |
eng
|
pubmed:journal |
|
pubmed:citationSubset |
IM
|
pubmed:chemical |
|
pubmed:status |
MEDLINE
|
pubmed:month |
Jan
|
pubmed:issn |
0014-2999
|
pubmed:author |
|
pubmed:issnType |
Print
|
pubmed:day |
2
|
pubmed:volume |
107
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
N
|
pubmed:pagination |
243-51
|
pubmed:dateRevised |
2006-11-15
|
pubmed:meshHeading |
pubmed-meshheading:3979426-Animals,
pubmed-meshheading:3979426-Autoradiography,
pubmed-meshheading:3979426-Brain,
pubmed-meshheading:3979426-Domperidone,
pubmed-meshheading:3979426-Freezing,
pubmed-meshheading:3979426-Kinetics,
pubmed-meshheading:3979426-Ligands,
pubmed-meshheading:3979426-Male,
pubmed-meshheading:3979426-Rats,
pubmed-meshheading:3979426-Rats, Inbred Strains,
pubmed-meshheading:3979426-Receptors, Dopamine,
pubmed-meshheading:3979426-Spiperone,
pubmed-meshheading:3979426-Sulpiride,
pubmed-meshheading:3979426-Tritium
|
pubmed:year |
1985
|
pubmed:articleTitle |
The use of [3H](-)-DO 710 as selective dopaminergic ligand for binding and autoradiographic studies.
|
pubmed:publicationType |
Journal Article,
In Vitro
|