rdf:type |
|
lifeskim:mentions |
umls-concept:C0000275,
umls-concept:C0009498,
umls-concept:C0027950,
umls-concept:C0030054,
umls-concept:C0033268,
umls-concept:C0086418,
umls-concept:C0205332,
umls-concept:C0699795,
umls-concept:C0870883,
umls-concept:C1261512,
umls-concept:C1304680,
umls-concept:C2004454
|
pubmed:issue |
2
|
pubmed:dateCreated |
1985-4-4
|
pubmed:abstractText |
Luminol-enhanced chemiluminescence demonstrated that 2-chloroadenosine inhibited complement-induced reactive oxygen metabolite production in human polymorphonuclear leucocytes. This inhibition was reversed by 8-phenyltheophylline. Binding of a [125I]-labelled monoclonal antibody against C9 to human PMN demonstrated removal of membrane attack complexes from the cell membranes, and in addition indicated inhibition of this process by 2-chloroadenosine. This compound also increased the percentage of complement-induced cell lysis of polymorphonuclear leucocytes.
|
pubmed:language |
eng
|
pubmed:journal |
|
pubmed:citationSubset |
IM
|
pubmed:chemical |
|
pubmed:status |
MEDLINE
|
pubmed:month |
Jan
|
pubmed:issn |
0006-291X
|
pubmed:author |
|
pubmed:issnType |
Print
|
pubmed:day |
31
|
pubmed:volume |
126
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
692-7
|
pubmed:dateRevised |
2006-11-15
|
pubmed:meshHeading |
pubmed-meshheading:3977885-2-Chloroadenosine,
pubmed-meshheading:3977885-Adenosine,
pubmed-meshheading:3977885-Antibodies, Monoclonal,
pubmed-meshheading:3977885-Cell Membrane,
pubmed-meshheading:3977885-Complement Activation,
pubmed-meshheading:3977885-Complement Inactivator Proteins,
pubmed-meshheading:3977885-Humans,
pubmed-meshheading:3977885-Immunoglobulin M,
pubmed-meshheading:3977885-Luminescent Measurements,
pubmed-meshheading:3977885-Neutrophils,
pubmed-meshheading:3977885-Oxygen
|
pubmed:year |
1985
|
pubmed:articleTitle |
2-Chloroadenosine inhibits complement-induced reactive oxygen metabolite production and recovery of human polymorphonuclear leucocytes attacked by complement.
|
pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|