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pubmed:abstractText |
Pretreatment of mice with the microsomal enzyme inducers and inhibitors modified the toxicity of lobeline sulfate. The intraperitoneal LD50 of lobeline sulfate following SKF 525-A (75 mg/kg), phenobarbital (PB), and 3-methylcholanthrene (3-MC) were 18.3, 85.5 and 82.1 mg/kg, respectively, as compared to that of saline treated controls, 55.3 mg/kg. Pretreatment of mice with disulfiram (DSF), diethylmaleate (DEM), or ethoxyquin hydrochloride (EQ-HC1) exhibited a very slight effect on the toxicity of lobeline sulfate. These results suggest that the hepatic microsomal monooxygenase system, but not glutathione (GSH), is involved in the detoxication of lobeline sulfate.
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