Linked Life Data

3967864

Source:http://linkedlifedata.com/resource/pubmed/id/3967864

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1985-3-18
pubmed:abstractText
Recent studies suggest that the serum level of Type III procollagen (PC-III) could be a valuable, noninvasive monitor of hepatic fibrogenesis. We have developed a sensitive and specific radioimmunoassay for PC-III procollagen isolated and purified from fetal goat skin which shows high cross-reaction for human PC-III. In a double-blind study, serum samples taken from 8 normal volunteers and 50 patients at the time of liver biopsy were assayed for PC-III. Each biopsy was reviewed without knowledge of the radioimmunoassay results, and old or active fibrosis was graded on a 0 to 3 (none, minimal, moderate, severe) scale. There was a significant difference between serum concentrations of PC-III in normals (mean +/- S.D. = 72 ng per ml +/- 8) as compared to patients with biopsy evidence of active fibrosis (mean +/- S.D. = 153 ng per ml +/- 12; p less than 0.001). The serum concentration of PC-III showed a good correlation (r = 0.58; p less than 0.001) with the histological grade of active lobular fibrosis. Measurement of PC-III is a noninvasive test for detection of active fibrosis in the liver.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0270-9139
pubmed:author
pubmed:issnType
Print
pubmed:volume
5
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
38-42
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:articleTitle
A radioimmunoassay procedure for type III procollagen: its use in the detection of hepatic fibrosis.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, U.S. Gov't, Non-P.H.S., Research Support, Non-U.S. Gov't