Linked Life Data

3960966

Source:http://linkedlifedata.com/resource/pubmed/id/3960966

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
1986-5-1
pubmed:abstractText
To investigate the pulmonary absorption rate of drugs in the anesthetized beagle dog, 5 ml of drug solution was administered into the lungs by rapid injection through a tracheal cannula. After various times, lungs were removed and assayed for unabsorbed drug. The dog absorbed lipid-insoluble drugs such as p-aminohippuric acid, mannitol, and procainamide ethobromide at the same rate as the rat, two times more rapidly than the rabbit, and approximately 2-3 times more slowly than the mouse and guinea pig. In contrast, the dog absorbed a lipid-soluble drug like procainamide at the same rate as the other four species. The results suggest that pulmonary absorption rates measured in small laboratory animals can be used to predict absorption rates in large animals.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0031-7012
pubmed:author
pubmed:issnType
Print
pubmed:volume
32
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
176-80
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1986
pubmed:articleTitle
Pulmonary absorption of drugs in the dog: comparison with other species.
pubmed:publicationType
Journal Article, Comparative Study, Research Support, U.S. Gov't, P.H.S.