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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
3
|
| pubmed:dateCreated |
1986-5-12
|
| pubmed:abstractText |
The study of pharmacokinetics of water-soluble 2-ethyl-6-methyl-3-hydroxypyridine salt (EM-3-HP) in rats has shown this substance to be quickly absorbed from the abdominal cavity of animals. Its maximal concentrations in the plasma, brain and liver were determined 2-3 hours later, with the following monoexponential decrease in EM-3-HP level with the elimination half-life of 2-6 hours observed. Considerable EM-3-HP tropism to membranes of endoplasmic reticulum in the liver and brain cells is suggested to cause its membranomodulatory effect and to facilitate its pharmacological activity.
|
| pubmed:language |
rus
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Mar
|
| pubmed:issn |
0365-9615
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
101
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
325-7
|
| pubmed:dateRevised |
2008-10-8
|
| pubmed:meshHeading |
pubmed-meshheading:3955219-Animals,
pubmed-meshheading:3955219-Antioxidants,
pubmed-meshheading:3955219-Kinetics,
pubmed-meshheading:3955219-Male,
pubmed-meshheading:3955219-Picolines,
pubmed-meshheading:3955219-Rats,
pubmed-meshheading:3955219-Solubility,
pubmed-meshheading:3955219-Time Factors,
pubmed-meshheading:3955219-Tissue Distribution
|
| pubmed:year |
1986
|
| pubmed:articleTitle |
[Pharmacokinetics of a water-soluble antioxidant from the class of 3-hydroxypyridines].
|
| pubmed:publicationType |
Journal Article,
English Abstract
|